Routine chromosomal analysis requires the study of
metaphase chromosomes in cultured cells. Results are usually
available in 1–3 weeks. Molecular genetic analysis by
fluorescence in situ hydridisation (FISH) studies is possible for
certain conditions. These studies are usually performed on
cultured cells, but in some cases (such as urgent prenatal
confirmation of trisomy 21) rapid results may be obtained by
analysis of interphase nuclei in uncultured cells.
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